Cytogenetic features of juvenile chronic myelogenous leukemia
نویسندگان
چکیده
منابع مشابه
Cytogenetic features of juvenile chronic myelogenous leukemia.
Consistent chromosomal abnormalities have been described in several leukemic disorders, but relatively little is known about the cytogenetic features of juvenile chronic myelogenous leukemia (JCML). We report the serial cytogenetic findings over a 2-yr period for a patient with JCML. A large subtelocentric marker chromosome was noted in all metaphases throughout the course of his disease and pr...
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Juvenile chronic myelogenous leukemia (JCML) is a myeloproliferative disease in which morbidity and mortality are primarily caused by nonhematopoietic organ failure from myelomonocytic infiltration or by failure of the normal bone marrow. Morphologic evidence of maturation arrest, karyotypic abnormalities, and progression to blast crisis are infrequent events. Viral infections and other reactiv...
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In chronic myelogenous leukemia (CML), the mature granulocytes originate from a stem cell line harboring an abnormal chromosome, therefore it is possible that metabolic-functional abnormalities occur in the morphologically mature cells. In the present study, the phagocytic activity including intracellular killing, nitro blue tetrazolium (NBT) reduction, and phagocytosis were studied in 37 CML p...
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Juvenile chronic myelogenous leukemia (JCML) is a rare malignant hematopoietic disorder representing only 2% of all childhood leukemias. The disease has a rapid course and has a median survival of less than 10 months when untreated or undertreated(l,2). Patients are often difficult to diagnose because of their clinical heterogeneity. A remarkable feature is increased synthesis of HbF and excess...
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ژورنال
عنوان ژورنال: Blood
سال: 1979
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v53.5.812.812